External validation of prognostic models for preeclampsia in a Dutch multicenter prospective cohort
Publication date
2019-03-20
Authors
Lamain-de Ruiter, Marije
Kwee, Anneke
Naaktgeboren, Christiana A.
Louhanepessy, Rebecca D
De Groot, Inge
Evers, Inge M
Groenendaal, Floris
Hering, Yolanda R
Huisjes, Anjoke J M
Kirpestein, Cornel
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Document Type
Article
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Abstract
Objective: To perform an external validation of all published prognostic models for first-trimester prediction of the risk of developing preeclampsia (PE). Methods: Women <14 weeks of pregnancy were recruited in the Netherlands. All systematically identified prognostic models for PE that contained predictors commonly available were eligible for external validation. Results: 3,736 women were included; 87 (2.3%) developed PE. Calibration was poor due to overestimation. Discrimination of 9 models for LO-PE ranged from 0.58 to 0.71 and of 9 models for all PE from 0.55 to 0.75. Conclusion: Only a few easily applicable prognostic models for all PE showed discrimination above 0.70, which is considered an acceptable performance.
Keywords
First trimester, external validation, preeclampsia, prognostic model, Models, Theoretical, Prognosis, Prospective Studies, Risk Assessment, Humans, Pre-Eclampsia/diagnosis, Pregnancy, Adult, Female, Obstetrics and Gynaecology, Internal Medicine, Journal Article, Multicenter Study, Validation Studies
Citation
Lamain-de Ruiter, M, Kwee, A, Naaktgeboren, C A, Louhanepessy, R D, De Groot, I, Evers, I M, Groenendaal, F, Hering, Y R, Huisjes, A J M, Kirpestein, C, Monincx, W M, Schielen, P C J I, Van 't Zelfde, A, Van Oirschot, C M, Vankan-Buitelaar, S A, Vonk, M A A W, Wiegers, T A, Zwart, J J, Moons, K G M, Franx, A & Koster, M P H 2019, 'External validation of prognostic models for preeclampsia in a Dutch multicenter prospective cohort', Hypertension in Pregnancy, vol. 38, no. 2, pp. 78-88. https://doi.org/10.1080/10641955.2019.1584210