Pigmentvlekken bij kinderen als uiting van een syndroom Een klinische benadering

Abstract

Hyperpigmented macules in children can be the first clinical sign of an underlying condition or syndrome. Café au lait maculae and lentigines are well-known examples. Café au lait maculae may be associated with syndromes such as neurofibromatosis type 1, Legius syndrome and McCune-Albright syndrome. Lentigines are seen in Peutz-Jeghers syndrome and Noonan syndrome with multiple lentigines (LEOPARD syndrome). Early diagnosis is important to agree on appropriate screening and surveillance for these children.