In-depth Characterization of Vaccine Breakthrough Infections With SARS-CoV-2 Among Health Care Workers in a Dutch Academic Medical Center
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Publication date
2022-01
Authors
Rümke, Lidewij
Groenveld, Femke C
van Os, Yvonne M G
Praest, Patrique
Tanja, Anniek A N
de Jong, Dorien
Symons, Jori
Schuurman, R.
Reinders, Tessa
Hofstra, Laura Marije
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Document Type
Article
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cc_by_nc_nd
Abstract
Severe acute respiratory syndrome coronavirus 2 infection after coronavirus disease 2019 vaccination raises concerns about the emergence of vaccine escape variants. Here we characterize 14 breakthrough infections among 5860 fully vaccinated Dutch health care workers ≥14 days after the final dose of vaccination with either BNT162b2, mRNA-1273, or Ad26.COV2.S. These breakthrough infections presented with regular B.1.1.7 (Alpha) and B.1.617.2 (Delta) variants and high viral loads, despite normal vaccine-induced B- and T-cell immune responses detected by live virus neutralization assays and ELISpot. High-risk exposure settings, such as in households, indicate a potential risk of viral transmission despite full vaccination.
Keywords
COVID-19, SARS-CoV-2, immunity, postvaccination infection, vaccine breakthrough, Oncology, Clinical Neurology
Citation
Rümke, L W, Groenveld, F C, van Os, Y M G, Praest, P, Tanja, A A N, de Jong, D T C M, Symons, J, Schuurman, R, Reinders, T, Hofstra, L M, Nierkens, S, Thijsen, S F T, Heron, M, Lebbink, R-J, Beekman, J M, Nijhuis, M & Wensing, A M J 2022, 'In-depth Characterization of Vaccine Breakthrough Infections With SARS-CoV-2 Among Health Care Workers in a Dutch Academic Medical Center', Open forum infectious diseases, vol. 9, no. 1, ofab553, pp. 1-6. https://doi.org/10.1093/ofid/ofab553