Incidence, Risk Factors and Outcome of Suspected Central Venous Catheter-related Infections in Critically Ill COVID-19 Patients: A Multicenter Retrospective Cohort Study
Publication date
2022-11-01
Authors
Exterkate, Lotte
van Tienhoven, Arne J
Haaksma, Mark E
Heldeweg, Micah L A
Fleuren, Lucas
Thoral, Patrick
Dam, Tariq A
Heunks, Leo M A
Gommers, Diederik
Cremer, Olaf
Editors
Advisors
Supervisors
Document Type
Article
Metadata
Show full item recordCollections
License
taverne
Abstract
Background: Aims of this study were to investigate the prevalence and incidence of catheter-related infection, identify risk factors, and determine the relation of catheter-related infection with mortality in critically ill COVID-19 patients. Methods: This was a retrospective cohort study of central venous catheters (CVCs) in critically ill COVID-19 patients. Eligible CVC insertions required an indwelling time of at least 48 hours and were identified using a full-admission electronic health record database. Risk factors were identified using logistic regression. Differences in survival rates at day 28 of follow-up were assessed using a log-rank test and proportional hazard model. Results: In 538 patients, a total of 914 CVCs were included. Prevalence and incidence of suspected catheter-related infection were 7.9% and 9.4 infections per 1,000 catheter indwelling days, respectively. Prone ventilation for more than 5 days was associated with increased risk of suspected catheter-related infection; odds ratio, 5.05 (95% confidence interval 2.12-11.0). Risk of death was significantly higher in patients with suspected catheter-related infection (hazard ratio, 1.78; 95% confidence interval, 1.25-2.53). Conclusions: This study shows that in critically ill patients with COVID-19, prevalence and incidence of suspected catheter-related infection are high, prone ventilation is a risk factor, and mortality is higher in case of catheter-related infection.
Keywords
catheter-related infections, Central venous catheters, COVID-19, intensive care, Taverne, Critical Care and Intensive Care Medicine, Emergency Medicine, Journal Article
Citation
Exterkate, L, van Tienhoven, A J, Haaksma, M E, Heldeweg, M L A, Fleuren, L, Thoral, P, Dam, T A, Heunks, L M A, Gommers, D, Cremer, O L, Bosman, R J, Rigter, S, Wils, E-J, Frenzel, T, Vlaar, A P, Dongelmans, D A, de Jong, R, Peters, M, Kamps, M J A, Ramnarain, D, Nowitzky, R, Nooteboom, F G C A, de Ruijter, W, Urlings-Strop, L C, Smit, E G M, Mehagnoul-Schipper, D J, Dormans, T, de Jager, C P C, Hendriks, S H A, Achterberg, S, Oostdijk, E, Reidinga, A C, Festen-Spanjer, B, Brunnekreef, G B, Cornet, A D, van den Tempel, W, Boelens, A D, Koetsier, P, Lens, J, Faber, H J, Karakus, A, Entjes, R, de Jong, P, Rettig, T C D, Arbous, S, Vonk, B, Machado, T, Girbes, A R J, Sieswerda, E, Elbers, P W G & Tuinman, P R 2022, 'Incidence, Risk Factors and Outcome of Suspected Central Venous Catheter-related Infections in Critically Ill COVID-19 Patients : A Multicenter Retrospective Cohort Study', Shock (Augusta, Ga.), vol. 58, no. 5, pp. 358-365. https://doi.org/10.1097/SHK.0000000000001994