Colorectal cancer stem cells : regulation of the phenotype and implications for therapy resistance
Publication date
2014-11-12
Authors
Emmink, B.L.
Editors
Advisors
Borel Rinkes, I.H.M.
Kranenburg, O.W.
Jimenez, C.R.
Supervisors
DOI
Document Type
Dissertation
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Abstract
In this thesis different aspects of cancer stem cells in colorectal cancer are discribed. We focus on the therapy resistance of cancer stem cells and the effect that reactive oxygen species and hypoxia have on the cancer stem cell phenotype. For this purpose a novel culture method to propagate cancer stem cells form resected tumor specimens was used.
Keywords
colorectal, cancer stem cells, reactive oxygen species, therapy resistance, phenotype