GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes
Publication date
2018-12-01
Authors
Franceschini, Nora
Giambartolomei, Claudia
de Vries, Paul S.
Finan, Chris
Bis, Joshua C.
Huntley, Rachael P.
Lovering, Ruth C.
Tajuddin, Salman M.
Winkler, Thomas W.
Graff, Misa
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Supervisors
Document Type
Article
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Abstract
Carotid artery intima media thickness (cIMT) and carotid plaque are measures of subclinical atherosclerosis associated with ischemic stroke and coronary heart disease (CHD). Here, we undertake meta-analyses of genome-wide association studies (GWAS) in 71,128 individuals for cIMT, and 48,434 individuals for carotid plaque traits. We identify eight novel susceptibility loci for cIMT, one independent association at the previously-identified PINX1 locus, and one novel locus for carotid plaque. Colocalization analysis with nearby vascular expression quantitative loci (cis-eQTLs) derived from arterial wall and metabolic tissues obtained from patients with CHD identifies candidate genes at two potentially additional loci, ADAMTS9 and LOXL4. LD score regression reveals significant genetic correlations between cIMT and plaque traits, and both cIMT and plaque with CHD, any stroke subtype and ischemic stroke. Our study provides insights into genes and tissue-specific regulatory mechanisms linking atherosclerosis both to its functional genomic origins and its clinical consequences in humans.
Keywords
General Chemistry, General Biochemistry,Genetics and Molecular Biology, General Physics and Astronomy
Citation
Franceschini, N, Giambartolomei, C, de Vries, P S, Finan, C, Bis, J C, Huntley, R P, Lovering, R C, Tajuddin, S M, Winkler, T W, Graff, M, Kavousi, M, Dale, C, Smith, A V, Hofer, E, van Leeuwen, E M, Nolte, I M, Lu, L, Scholz, M, Sargurupremraj, M, Pitkänen, N, Franzén, O, Joshi, P K, Noordam, R, Marioni, R E, Hwang, S J, Musani, S K, Schminke, U, Palmas, W, Isaacs, A, Correa, A, Zonderman, A B, Hofman, A, Teumer, A, Cox, A J, Uitterlinden, A G, Wong, A, Smit, A J, Newman, A B, Britton, A, Ruusalepp, A, Sennblad, B, Hedblad, B, Pasaniuc, B, Penninx, B W, Langefeld, C D, Franco, O H, van der Laan, S W, de Bakker, P I W, Pulit, S L, van der Harst, P & MEGASTROKE Consortium 2018, 'GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes', Nature Communications, vol. 9, no. 1, 5141. https://doi.org/10.1038/s41467-018-07340-5