Acute heart failure: mechanisms and pre-clinical models-a Scientific Statement of the ESC Working Group on Myocardial Function
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Publication date
2023-10-01
Authors
Ciccarelli, Michele
Pires, Inês Falcão
Bauersachs, Johann
Bertrand, Luc
Beauloye, Christophe
Dawson, Dana
Hamdani, Nazha
Hilfiker-Kleiner, Denise
Van Laake, Linda W.
Lezoualc'h, Frank
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Supervisors
Document Type
Article
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taverne
Abstract
While chronic heart failure (CHF) treatment has considerably improved patient prognosis and survival, the therapeutic management of acute heart failure (AHF) has remained virtually unchanged in the last decades. This is partly due to the scarcity of pre-clinical models for the pathophysiological assessment and, consequently, the limited knowledge of molecular mechanisms involved in the different AHF phenotypes. This scientific statement outlines the different trajectories from acute to CHF originating from the interaction between aetiology, genetic and environmental factors, and comorbidities. Furthermore, we discuss the potential molecular targets capable of unveiling new therapeutic perspectives to improve the outcome of the acute phase and counteracting the evolution towards CHF.
Keywords
Acute Disease, Chronic Disease, Heart Failure/diagnosis, Humans, Prognosis, Risk Factors, Taverne, Journal Article, Research Support, Non-U.S. Gov't
Citation
Ciccarelli, M, Pires, I F, Bauersachs, J, Bertrand, L, Beauloye, C, Dawson, D, Hamdani, N, Hilfiker-Kleiner, D, van Laake, L W, Lezoualc'h, F, Linke, W A, Lunde, I G, Rainer, P P, Rispoli, A, Visco, V, Carrizzo, A, Ferro, M D, Stolfo, D, van der Velden, J, Zacchigna, S, Heymans, S, Thum, T & Tocchetti, C G 2023, 'Acute heart failure : mechanisms and pre-clinical models-a Scientific Statement of the ESC Working Group on Myocardial Function', Cardiovascular research, vol. 119, no. 14, pp. 2390-2404. https://doi.org/10.1093/cvr/cvad088