Upregulation of Class I MHC on Neuroblastoma Cells By NK Cell Exposure for Enhanced CTL Reactivity
Publication date
2015-02
Authors
Nierkens, Stefan
Spel, Lotte
van der Steen, Dirk
Blokland, Nina
Heemskerk, Mirjam
Boelens, Jaap J.
Boes, Marianne
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Abstract
Neuroblastoma is the most common solid tumor in pediatric patients, with a clear unmet need as survival rates are <20% for stage IV disease. As adjuvant immunotherapy is considered to have additional anti-tumor activity we aim to increase cytotoxic T lymphocyte (CTL)-mediated immune surveillance in neuroblastoma patients by administration of a dendritic cell-based vaccine. Neuroblastoma has developed mechanisms to circumvent CTL recognition; therefore it is our aim to find clinical strategies to make neuroblastoma susceptible for CTL killing
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Nierkens, S, Spel, L, van der Steen, D, Blokland, N, Heemskerk, M, Boelens, J & Boes, M 2015, 'Upregulation of Class I MHC on Neuroblastoma Cells By NK Cell Exposure for Enhanced CTL Reactivity', Biology of Blood and Marrow Transplantation, vol. 21, no. 2, pp. S240-S240.