Fatal Carbapenem Resistance Development in Pseudomonas Aeruginosa Under Meropenem Monotherapy, Caused by Mutations in the Oprd Outer Membrane Porin
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Publication date
2019-04
Authors
Fluit, Ad C
Rentenaar, R. J.
Ekkelenkamp, Miquel B.
Severs, Tim T
Mavinkurve-Groothuis, Annelies M.
Rogers, Malbert
Bruin, MCA
Wolfs, Tom
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Document Type
Article
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taverne
Abstract
A 13-year old neutropenic boy succumbed to bacteremia and sepsis with a Pseudomonas aeruginosa strain that rapidly developed resistance to carbapenems during meropenem monotherapy. Whole genome sequencing of the susceptible and resistant blood culture isolates revealed the meropenem-resistant phenotype to be caused by truncation of the oprD gene, which added to a pre-existing inactivated mexR gene.
Keywords
Pseudomonas aeruginosa, febrile neutropenia, imipenem resistant, meropenem resistant, mexR, oprD, sepsis, Taverne, Microbiology (medical), Infectious Diseases, Pediatrics, Perinatology, and Child Health, Journal Article
Citation
Fluit, A C, Rentenaar, R J, Ekkelenkamp, M B, Severs, T T, Mavinkurve-Groothuis, A M C, Rogers, M R C, Bruin, M C A & Wolfs, T F W 2019, 'Fatal Carbapenem Resistance Development in Pseudomonas Aeruginosa Under Meropenem Monotherapy, Caused by Mutations in the Oprd Outer Membrane Porin', The Pediatric infectious disease journal, vol. 38, no. 4, pp. 398-399. https://doi.org/10.1097/INF.0000000000002244