Sulfated N-linked carbohydrate chains in porcine thyroglobulin

Publication date

1988

Authors

Vliegenthart, J.F.G.
Kamerling, J.P.
Rijkse, I.
Maas, A.A.M.
Kuik, J.A. van

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Abstract

N-linked carbohydrate chains of porcine thyroglobulin were released by the hydrazinolysis procedure. The resulting mixture of oligosaccharide-alditols was fractionated by high-voltage paper electrophoresis, the acidic fractions were further separated by high-performance liquid chromatography on Lichrosorb-NH2, and analyzed by 500-MHz 1H-NMR spectroscopy and, partially, by permethylation analysis. Of the acidic oligosaccharide-alditols, the following sulfated carbohydrate chains could be identified:

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