Physicochemical characterization of degradable thermosensitive polymeric micelles
Publication date
2004-10-12
Authors
Soga, Osamu
van Nostrum, Rene
Ramzi, Aissa
Visser, Tom
Soulimani, F.
Frederik, Peter M.
Bomans, Paul H.H.
Hennink, Wim E
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Advisors
Supervisors
Document Type
Article
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taverne
Abstract
The physicochemical characterization of degradable thermosensitive polymeric micelles was presented. Dynamic light scattering measurements showed that these block copolymers form polymeric micelles in water with a size of 50 nm by heating of an aqueous polymer solution. Fluorescence spectroscopy measurements with pyrene loaded in the hydrophobic core of the micelles showed that these micelles were incubated at pH 8.6. It was found that the micelles possess a spherical shape with a narrow size distribution.
Keywords
Farmacie/Biofarmaceutische wetenschappen (FARM), Medical technology, Farmacie(FARM), Biomedische technologie en medicijnen, Pharmacology, Taverne, General Materials Science, Condensed Matter Physics, Surfaces and Interfaces, Spectroscopy, Electrochemistry, International
Citation
Soga, O, Van Nostrum, C F, Ramzi, A, Visser, T, Soulimani, F, Frederik, P M, Bomans, P H H & Hennink, W E 2004, 'Physicochemical characterization of degradable thermosensitive polymeric micelles', Langmuir, vol. 20, no. 21, pp. 9388-9395. https://doi.org/10.1021/la048354h