"Bound" globulin in the skin of patients with chronic discoid lupus erythematosus and systemic lupus erythematosus

Abstract

In what respect chronic discoid lupus erythematosus is related to systemic lupus erythematosus is still uncertain. In discoid lupus the lupus-erythematosus (L.E.) phenomenon is negative, and the history does not suggest vascular lesions or involvement of serous membranes. In both diseases the pathogenesis of the skin lesions is unknown, but they are probably the result of an autoimmune mechanism.