Expression of MHC genes in adenovirus-tranformed cells
Publication date
1984
Authors
Vaessen, R.T.M.J.
Bernards, R.A.
Oostra, B.A.
Houweling, A.
Jochemsen, A.G.
Bos, J.L.
Eb, A.J. van der
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DOI
Document Type
Article in proceedings
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Abstract
Class I MHC gene expression is drastically reduced in
Ad12-, but not in Ad5-transformed primary cells of three
different rodent species. Here we demonstrate that class I
expression in Ad12-transformed primary Baby Rat Kidney
cells can be reactivated by AdS.
We also show that class I gene expression is switched
off only when primary cells were transformed by Ad12, but
not when established cell lines were transformed.