Clinically established biodegradable long acting injectables: An industry perspective
Publication date
2020-12
Authors
Nkanga, Christian Isalomboto
Fisch, Andreas
Rad-Malekshahi, Mazda
Romic, Marieta Duvnjak
Kittel, Birgit
Ullrich, Thomas
Wang, Jing
Krause, Rui Werner Maçedo
Adler, Sabine
Lammers, Twan
Editors
Advisors
Supervisors
Document Type
Article
Metadata
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License
taverne
Abstract
Long acting injectable formulations have been developed to sustain the action of drugs in the body over desired periods of time. These delivery platforms have been utilized for both systemic and local drug delivery applications. This review gives an overview of long acting injectable systems that are currently in clinical use. These products are categorized in three different groups: biodegradable polymeric systems, including microparticles and implants; micro and nanocrystal suspensions and oil-based formulations. Furthermore, the applications of these drug delivery platforms for the management of various chronic diseases are summarized. Finally, this review addresses industrial challenges regarding the development of long acting injectable formulations.
Keywords
Long acting injectables, Extended release, Drug delivery, PLGA microparticles, Microspheres, Implants, In situ forming implants, Drug crystals, Oil-based formulations, Drug crystal suspensions, Taverne
Citation
Nkanga, C I, Fisch, A, Rad-Malekshahi, M, Romic, M D, Kittel, B, Ullrich, T, Wang, J, Krause, R W M, Adler, S, Lammers, T, Hennink, W E & Ramazani, F 2020, 'Clinically established biodegradable long acting injectables : An industry perspective', Advanced Drug Delivery Reviews, vol. 167, pp. 19-46. https://doi.org/10.1016/j.addr.2020.11.008