Education differentially contributes to cognitive reserve across racial/ethnic groups
Publication date
2021-01
Authors
Avila, Justina F
Rentería, Miguel Arce
Jones, Richard N
Vonk, Jet M J
Turney, Indira
Sol, Ketlyne
Seblova, Dominika
Arias, Franchesca
Hill-Jarrett, Tanisha
Levy, Shellie-Anne
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Advisors
Supervisors
Document Type
Article
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taverne
Abstract
INTRODUCTION: We examined whether educational attainment differentially contributes to cognitive reserve (CR) across race/ethnicity. METHODS: A total of 1553 non-Hispanic Whites (Whites), non-Hispanic Blacks (Blacks), and Hispanics in the Washington Heights-Inwood Columbia Aging Project (WHICAP) completed structural magnetic resonance imaging. Mixture growth curve modeling was used to examine whether the effect of brain integrity indicators (hippocampal volume, cortical thickness, and white matter hyperintensity [WMH] volumes) on memory and language trajectories was modified by education across racial/ethnic groups. RESULTS: Higher educational attainment attenuated the negative impact of WMH burden on memory (β = -0.03; 99% CI: -0.071, -0.002) and language decline (β = -0.024; 99% CI:- 0.044, -0.004), as well as the impact of cortical thinning on level of language performance for Whites, but not for Blacks or Hispanics. DISCUSSION: Educational attainment does not contribute to CR similarly across racial/ethnic groups.
Keywords
cognitive aging, cognitive reserve, education, racial/ethnic differences, Taverne, Clinical Neurology, Geriatrics and Gerontology, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Health Policy, Developmental Neuroscience, Epidemiology, Journal Article
Citation
Avila, J F, Rentería, M A, Jones, R N, Vonk, J M J, Turney, I, Sol, K, Seblova, D, Arias, F, Hill-Jarrett, T, Levy, S-A, Meyer, O, Racine, A M, Tom, S E, Melrose, R J, Deters, K, Medina, L D, Carrión, C I, Díaz-Santos, M, Byrd, D R, Chesebro, A, Colon, J, Igwe, K C, Maas, B, Brickman, A M, Schupf, N, Mayeux, R & Manly, J J 2021, 'Education differentially contributes to cognitive reserve across racial/ethnic groups', Alzheimer's & Dementia, vol. 17, no. 1, pp. 70-80. https://doi.org/10.1002/alz.12176