Micro cell vesicle technology (mCVT): a novel hybrid system of gene delivery for hard-to-transfect (HTT) cells
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Publication date
2020-09-21
Authors
Ou, Yi-Hsuan
Zou, Shui
Goh, Wei Jiang
Chong, Suet Yen
Venkatesan, Gopalakrishnan
Wacker, Matthias G
Storm, Gert
Wang, Jiong-Wei
Czarny, Bertrand
Pastorin, Giorgia
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Abstract
A hybrid gene delivery platform, micro Cell Vesicle Technology (mCVT), produced from the fusion of plasma membranes and cationic lipids, is presently used to improve the transfection efficiency of hard-to-transfect (HTT) cells. The plasma membrane components of mCVTs impart specificity in cellular uptake and reduce cytotoxicity in the transfection process, while the cationic lipids complex with the genetic material and provide structural integrity to mCVTs.
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Ou, Y-H, Zou, S, Goh, W J, Chong, S Y, Venkatesan, G, Wacker, M G, Storm, G, Wang, J-W, Czarny, B, Pastorin, G & Woon, E C Y 2020, 'Micro cell vesicle technology (mCVT) : a novel hybrid system of gene delivery for hard-to-transfect (HTT) cells', Nanoscale, vol. 12, no. 35, pp. 18022-18030. https://doi.org/10.1039/d0nr03784b