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Solving the Mysteries of Dementia: FTD Mutant Tau Impairs Structural Axon Initial Segment Plasticity

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Publication date

2019-11-06

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Lipka, JoannaISNI 0000000419569766
Hoogenraad, Casper C.ISNI 0000000396512854

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DOI

https://doi.org/10.1016/j.neuron.2019.10.021

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Article

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Abstract

Accumulation of abnormal Tau is a characteristic feature of a number of neurodegenerative disorders, called tauopathies. What is the reason for Tau toxicity in neuronal cells? In this issue of Neuron, Sohn et al. (2019) found that FTD mutant Tau-V337M blocks axon initial segment (AIS) plasticity, causing neuronal hyperexcitability.

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Lipka, J & Hoogenraad, C C 2019, 'Solving the Mysteries of Dementia : FTD Mutant Tau Impairs Structural Axon Initial Segment Plasticity', Neuron, vol. 104, no. 3, pp. 429-430. https://doi.org/10.1016/j.neuron.2019.10.021

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http://hdl.handle.net/1874/389340