Phenotype Standardization for Statin-Induced Myotoxicity
Publication date
2014-10
Authors
Alfirevic, A.
Neely, D.
Armitage, J.
Chinoy, H.
Cooper, R. G.
Laaksonen, R.
Carr, D. F.
Bloch, K. M.
Fahy, J.
Hanson, A.
Editors
Advisors
Supervisors
Document Type
Article
Metadata
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License
cc_by_nc_nd
Abstract
Statins are widely used lipid-lowering drugs that are effective in reducing cardiovascular disease risk. Although they are generally well tolerated, they can cause muscle toxicity, which can lead to severe rhabdomyolysis. Research in this area has been hampered to some extent by the lack of standardized nomenclature and phenotypic definitions. We have used numerical and descriptive classifications and developed an algorithm to define statin-related myotoxicity phenotypes, including myalgia, myopathy, rhabdomyolysis, and necrotizing autoimmune myopathy.Clinical Pharmacology and Therapeutics (2014); advance online publication 02 July 2014. doi:10.1038/clpt.2014.121.
Keywords
Pharmacology (medical), Pharmacology, SDG 3 - Good Health and Well-being
Citation
Alfirevic, A, Neely, D, Armitage, J, Chinoy, H, Cooper, R G, Laaksonen, R, Carr, D F, Bloch, K M, Fahy, J, Hanson, A, Yue, Q Y, Wadelius, M, Maitland-van Der Zee, A H, Voora, D, Psaty, B M, Palmer, C N A & Pirmohamed, M 2014, 'Phenotype Standardization for Statin-Induced Myotoxicity', Clinical Pharmacology and Therapeutics, vol. 96, no. 4, pp. 470-476. https://doi.org/10.1038/clpt.2014.121