Confined migration: Microtubules control the cell rear
Publication date
2024-08-05
Authors
Thery, Manuel
Akhmanova, Anna
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taverne
Abstract
Cell migration through complex 3D environments relies on the interplay between actin and microtubules. A new study shows that, when cells pass through narrow constrictions, CLASP-dependent microtubule stabilisation at the cell rear controls actomyosin contractility to enable nuclear translocation and preserve cell integrity.
Keywords
Taverne, General Biochemistry,Genetics and Molecular Biology, General Agricultural and Biological Sciences
Citation
Thery, M & Akhmanova, A 2024, 'Confined migration : Microtubules control the cell rear', Current Biology, vol. 34, no. 15, pp. R728-R731. https://doi.org/10.1016/j.cub.2024.06.045