The occurrence of lipidic particles in lipid bilayers as seen by 31P NMR and freeze-fracture electron-microscopy
Publication date
1979-08-07
Authors
Kruijff, B. de
Verkleij, A.J.
Echteld, C.J.A. van
Gerritsen, W.J.
Mombers, C.
Noordam, P.C.
Gier, J. de
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Article
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Abstract
A new type of lipid organization is observed in mixtures of phosphatidylcholine with cardiolipin (in the presence of Ca2+), monoglucosyldiglyceride and phosphatidylethanolamine (in the presence of cholesterol). This phase is characterised by an isotropic 31P NMR signal and is visualised by freeze-fracturing as particles and pits on the fracture faces of the lipid bilayer. As the most favourable model for this phase we propose the inverted micelle sandwiched in between the two monolayers of the lipid bilayer.
Keywords
31P-NMR, lipid particles, freeze fracture, inverted micelle