Trilateral retinoblastoma in transgenic mice
Publication date
1989
Authors
Bernards, R.A.
O'Brien, J.M.
Marcus, D.M.
Niffenegger, A.S
Carpenter, J.L.
Windle, J.J.
Mellon, P.
Albert, D.M.
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DOI
Document Type
Article
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Abstract
Retinoblastoma, a heritable malignancy, occurs in the eyes of
children at a median age of 2 years. It is a malignancy which has been
widely studied as a model for genetic predisposition to cancer. The
disease occurs in both heritable and nonheritable forms. Thirty to 40% of
children with retinoblastoma have a heritable form of the disease. The
other 60% to 70% of affected children have spontaneous somatic mutations
which will not be transmitted to their own offspring.