Signaling switches: Metabolism regulates gastruloid self-organization

Publication date

2025-05-01

Authors

Rodríguez-Colman, Maria J
Sonnen, Katharina F

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Supervisors

Document Type

Comment

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taverne

Abstract

Metabolic regulation of embryonic development is increasingly recognized. Villaronga-Luque et al.1 and Stopornwongkul et al.2 show that metabolic activity influences gastruloid formation from mouse embryonic stem cells, revealing that the balance between glycolysis and oxidative phosphorylation regulates cell fate decisions during gastruloid self-organization.

Keywords

Animals, Glycolysis, Mice, Mouse Embryonic Stem Cells/metabolism, Organoids/metabolism, Oxidative Phosphorylation, Signal Transduction, Taverne, Journal Article

Citation

Rodríguez Colman, M J & Sonnen, K F 2025, 'Signaling switches : Metabolism regulates gastruloid self-organization', Cell stem cell, vol. 32, no. 5, pp. 673-675. https://doi.org/10.1016/j.stem.2025.04.005