The behaviour of LDH-3 in patients with malignant diseases during therapy with cytostatic drugs and prednisone, studied by LDH-isoenzyme electrophoresis on cellulose acetate
Publication date
1975-01
Authors
Gennip, A.H. van
Tabak-van Gorcum, J.A.
Taminiau, J.A.J.M.
Wadman, S.K.
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Article
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Abstract
A modified method used for the quantitative estimation of LDH-isoenzymes in serum after electrophoresis on cellulose acetate is described.
Total LDH-activity and isoenzyme distribution in serum samples of capillary blood are compared to those in samples collected by venipuncture.
Total LDH-values and LDH-distributions both in 29 normal children and 14 children with malignant diseases are given.
When studying the LDH-distribution in serum samples of children with malignant diseases a significantly decreased LDH-3 was found in many patients. LDH-4 and LDH-5 were also reduced. It was noted that these children all received therapy with prednisone. Possible explanations are discussed.