Bing–Neel Syndrome: Update on Diagnosis and Treatment
Publication date
2022-12
Authors
Wong, Evangeline Y.
D’Sa, Shirley
Minnema, Monique
Castillo, Jorge J.
Talaulikar, Dipti
Editors
Advisors
Supervisors
Document Type
Article
Metadata
Show full item recordCollections
License
cc_by
Abstract
Bing–Neel syndrome (BNS) is a rare neurological complication of Waldenström macroglobulinaemia. We highlight key issues in clinical presentation, diagnosis, and treatment while focusing on new and emerging therapies available for patients diagnosed with BNS. It is anticipated that further development of Bruton Tyrosine Kinase (BTK) inhibitors and less toxic chemoimmunotherapies will improve treatment delivery and response.
Keywords
Bing–Neel syndrome, BTK inhibitors, central nervous system involvement, ibrutinib, lymphoplasmacytic lymphoma, orbital involvement, Waldenström macroglobulinaemia, Hematology
Citation
Wong, E Y, D’Sa, S, Minnema, M C, Castillo, J J & Talaulikar, D 2022, 'Bing–Neel Syndrome : Update on Diagnosis and Treatment', Hemato, vol. 3, no. 4, pp. 758-770. https://doi.org/10.3390/hemato3040051