Factors associated with swallowing dysfunction in patients with head and neck cancer
Publication date
2023-07
Authors
Vermaire, Jorine A.
Raaijmakers, Niels
Monninkhof, E M
Leeuw, Irma M. Verdonck-de
Terhaard, Chris H J
Speksnijder, Caroline M.
Editors
Advisors
Supervisors
Document Type
Article
Metadata
Show full item recordCollections
License
cc_by_nc_nd
Abstract
Background: The aim of this prospective cohort study was to investigate swallowing function in relation to personal and clinical factors among patients with head and neck cancer (HNC) from diagnosis up to 2 years after treatment. Methods: The 100 ml water swallow test was measured before treatment, and 3, 6, 12, and 24 months after treatment. Linear mixed-effects model analysis was conducted to investigate changes over time and the association with personal (sex and age) and clinical (tumor site, tumor stage, and treatment modality) factors. Results: Among 128 included patients, number of swallows increased from baseline to 3 months after treatment and decreased to baseline again at 6 months after treatment. The number of swallows was associated with age and treatment modality. Conclusions: In patients with HNC, swallowing (dys)function changes over time with the worst score 3 months after treatment. A higher age and being treated with surgery are factors associated with swallowing dysfunction over time.
Keywords
100 ml water swallowing test, head and neck cancer, linear mixed model, swallowing dysfunction, 100 ml water swallowing test, General Dentistry, Otorhinolaryngology
Citation
Vermaire, J A, Raaijmakers, C P J, Monninkhof, E M, Leeuw, I M V, Terhaard, C H J & Speksnijder, C M 2023, 'Factors associated with swallowing dysfunction in patients with head and neck cancer', Oral Diseases, vol. 29, no. 5, pp. 1937-1946. https://doi.org/10.1111/odi.14192