The corticosterone-enhancing effects of the 5-HT(1A) receptor antagonist, (S)-UH301, are not mediated by the 5-HT(1A) receptor
Publication date
1995-01-14
Authors
Groenink, L.
Van der Gugten, J.
Mos, J.
Maes, R.A.A.
Olivier, Berend
Editors
Advisors
Supervisors
Document Type
Article
Metadata
Show full item recordCollections
License
cc_by
Abstract
We tried to antagonize the endocrine and behavioural changes induced by the selective 5-HT(1A) receptor agonist, flesinoxan, with the putative 5-HT(1A) receptor antagonist, (S)-UH301 ((S)-5-fluoro-8-hydroxy-2-(di-n-propylamino)tetralin). The interaction of (S)-UH301 (3 and 10 mg/kg s.c.) with flesinoxan (3 mg/kg s.c.) showed no antagonistic effects of (S)-UH301 on flesinoxan-induced corticosterone secretion. In fact, like flesinoxan (1 and 3 mg/kg s.c.), (S)-UH301 (3 and 10 mg/kg s.c.) itself dose dependently increased plasma corticosterone levels. Unlike flesinoxan, (S)-UH301 did not induce hyperglycemia, lower lip retraction and flat body posture. Moreover, flesinoxan-induced hyperglycemia and behavioural changes were effectively antagonized by (S)-UH301, showing potent 5-HT(1A) receptor antagonistic effects of (S)-UH301. Therefore we conclude that (S)-UH301 is a potent 5-HT(1A) receptor antagonist and that the (S)-UH301-induced corticosterone secretion is mediated by a non-5-HT(1A) receptor mechanism.
Keywords
(S)-UH301, 5-HT (5-hydroxytryptamine serotonin, 5-HT[1A] receptor, Behavioral syndrome, Corticosterone, Flesinoxan, Glucose, 2 dipropylamino 5 fluoro 8 hydroxytetralin, corticosterone, flesinoxan, glucose, serotonin 1A agonist, serotonin 1A antagonist, serotonin 1A receptor, animal experiment, article, behavior, body position, controlled study, corticosterone release, drug antagonism, drug mechanism, hyperglycemia, lip, male, nonhuman, priority journal, rat, subcutaneous drug administration, Taverne
Citation
Groenink, L, Van der Gugten, J, Mos, J, Maes, R A A & Olivier, B 1995, 'The corticosterone-enhancing effects of the 5-HT(1A) receptor antagonist, (S)-UH301, are not mediated by the 5-HT(1A) receptor', European Journal of Pharmacology, vol. 272, no. 2-3, pp. 177-183. https://doi.org/10.1016/0014-2999(94)00645-N