Sarcoidosis-related hypercalcaemia due to production of parathyroid hormone-related peptide
Publication date
2015
Authors
van Raalte, Daniel H
Goorden, Susan M
Kemper, Evelien A
Brosens, Lodewijk A
ten Kate, Reinier W
Editors
Advisors
Supervisors
Document Type
Article
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taverne
Abstract
Hypercalcaemia is frequently observed in patients with sarcoidosis. This is classically attributed to ectopic production of 1,25 dihydroxy vitamin D by sarcoid granulomas. We present a case of sarcoidosis-related hypercalcaemia with normal vitamin D levels. In this patient, production of parathyroid hormone-related peptide (PTHrp) was the cause for sarcoidosis-induced hypercalcaemia. As such, plasma PTHrp levels were increased and bone marrow granulomas stained positively for PTHrp expression. Medium-dose prednisolone treatment improved symptoms of sarcoidosis and normalised serum calcium, and PTHrp concentrations. Thus, production of PTHrp may be the cause for hypercalcaemia in some patients with sarcoidosis.
Keywords
Taverne, Case Reports, Journal Article
Citation
van Raalte, D H, Goorden, S M, Kemper, E A, Brosens, L A A & ten Kate, R W 2015, 'Sarcoidosis-related hypercalcaemia due to production of parathyroid hormone-related peptide', BMJ Case Reports [E], vol. 2015. https://doi.org/10.1136/bcr-2015-210189