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Cell Polarity: Getting the PARty Started

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Cell_polarity.pdf (491.7 KB)

Publication date

2019-07-08

Authors

Boxem, MikeORCID 0000-0003-3966-4173ISNI 0000000394154459
van den Heuvel, SanderISNI 0000000388487273

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DOI

https://doi.org/10.1016/j.cub.2019.05.032

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Article

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Utrecht University Repository
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Abstract

Polarity establishment is a key developmental process, but what determines its timing is poorly understood. New research in Caenorhabditis elegans demonstrates that the PAR polarity system extensively reconfigures before becoming competent to polarize. By inhibiting membrane localization of anterior PAR proteins, AIR-1 (aurora A) and PLK-1 (polo kinase) prevent premature polarization.

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Citation

Boxem, M & van den Heuvel, S 2019, 'Cell Polarity : Getting the PARty Started', Current Biology, vol. 29, no. 13, pp. R637-R639. https://doi.org/10.1016/j.cub.2019.05.032

URI

http://hdl.handle.net/1874/384400