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FoldIndex((c)): a simple tool to predict whether a given protein sequence is intrinsically unfolded

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Publication date

2005-08-15

Authors

Prilusky, J
Felder, CE
Zeev-Ben-Mordehai, TzviyaISNI 0000000492962767
Rydberg, EH
Man, O
Beckmann, J.S.
Silman, I.
Sussman, J.L.

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DOI

https://doi.org/10.1093/bioinformatics/bti537

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Article

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Utrecht University Repository

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Abstract

An easy-to-use, versatile and freely available graphic web server, FoldIndex© is described: it predicts if a given protein sequence is intrinsically unfolded implementing the algorithm of Uversky and co-workers, which is based on the average residue hydrophobicity and net charge of the sequence. FoldIndex© has an error rate comparable to that of more sophisticated fold prediction methods. Sliding windows permit identification of large regions within a protein that possess folding propensities different from those of the whole protein.

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Prilusky, J, Felder, CE, Zeev-Ben-Mordehai, T, Rydberg, EH, Man, O, Beckmann, J S, Silman, I & Sussman, J L 2005, 'FoldIndex((c)) : a simple tool to predict whether a given protein sequence is intrinsically unfolded', Bioinformatics, vol. 21, no. 16, pp. 3435-3438. https://doi.org/10.1093/bioinformatics/bti537

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https://dspace.library.uu.nl/handle/1874/357755