Update to RIFM fragrance ingredient safety assessment, 2H-indeno[4,5b] furan, decahydro-2,2,6,6,7,8,8-heptamethyl, CAS Registry Number 476332-65-7

Abstract

2H-Indeno[4,5b] furan, decahydro-2,2,6,6,7,8,8-heptamethyl was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, photoirritation/photoallergenicity, skin sensitization, and environmental safety. Data show that 2H-indeno[4,5b] furan, decahydro-2,2,6,6,7,8,8-heptamethyl is not genotoxic. Data on 2H-indeno[4,5b] furan, decahydro-2,2,6,6,7,8,8-heptamethyl provide a calculated Margin of Exposure (MOE) > 100 for the repeated dose toxicity and reproductive toxicity endpoints. Data provided 2H-indeno[4,5b] furan, decahydro-2,2,6,6,7,8,8-heptamethyl a No Expected Sensitization Induction Level (NESIL) of 2200 μg/cm2for the skin sensitization endpoint. The photoirritation/photoallergenicity endpoints were evaluated based on ultraviolet/visible (UV/Vis) spectra; 2H-indeno[4,5b] furan, decahydro-2,2,6,6,7,8,8-heptamethyl is not expected to be photoirritating/photoallergenic. The local respiratory toxicity endpoint was evaluated using the Threshold of Toxicological Concern (TTC) for a Cramer Class III material, and the exposure to 2H-indeno[4,5b] furan, decahydro-2,2,6,6,7,8,8-heptamethyl is below the TTC (0.47 mg/day). The environmental endpoints were evaluated; 2H-indeno[4,5b] furan, decahydro-2,2,6,6,7,8,8-heptamethyl was found not to be Persistent, Bioaccumulative, and Toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards, and its risk quotients, based on its current volume of use (VoU) in Europe and North America (i.e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]), are <1.