High occurrence of antihistamine resistance in patients with recurrent idiopathic angioedema
Publication date
2019-07-12
Authors
Hofman, Zonne L M
Van West, Nikki
Hack, Erik
Knulst, André
Maas, Coen
Röckmann, H
Editors
Advisors
Supervisors
Document Type
Letter
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Abstract
Antihistamines are the most prescribed therapy in recurrent idiopathic angioedema, yet little is known about their efficacy. Herein, we report on clinical improvement with antihistamine therapy in 120 patients evaluating angioedema attack frequency. A high incidence (36%) of antihistamine refractory cases was observed. Forty percent of patients on antihistamine prophylaxis suffered from 1 or more angioedema attacks per month. Our findings stress the need for additional treatment options for recurrent idiopathic angioedema.
Keywords
Angioedema, Antihistamines, Idiopathic angioedema, Omalizumab, Immunology and Allergy, Immunology, Pulmonary and Respiratory Medicine, Journal Article
Citation
Hofman, Z L M, Van West, N, Hack, C E, Knulst, A C, Maas, C & Röckmann, H 2019, 'High occurrence of antihistamine resistance in patients with recurrent idiopathic angioedema', Clinical and Translational Allergy, vol. 9, no. 1, 35. https://doi.org/10.1186/s13601-019-0274-7