Patent ductus arteriosus and brain volume
Publication date
2016-04-01
Authors
Lemmers, Petra Maria Anna
Benders, M.
D'Ascenzo, Rita
Zethof, Jorine
Alderliesten, Thomas
Kersbergen, Karina J.
Išgum, Ivana
de Vries, Linda S
Groenendaal, Floris
van Bel, Frank
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Document Type
Article
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Abstract
Background and Objectives: A hemodynamically significant patent ductus arteriosus (PDA) can compromise perfusion and oxygenation of the preterm brain. Reports suggest that PDA is associated with increased mortality and morbidity. We hypothesize that long-standing low cerebral oxygenation due to PDA might affect brain volume at term equivalent age. Methods: Observational study in 140 infants investigating the relationship between nearinfrared spectroscopy-monitored cerebral oxygen saturation (rScO2) and MRI-assessed regional brain volume and maturation of the posterior limb of the internal capsule at termequivalent age in 3 groups: those whose PDA closed with indomethacin, those who needed additional surgical closure, and matched controls. Results: The surgery group had the lowest rScO2 values before closure (n = 35), 48% ± 9.7% (mean ± SD) as compared with the indomethacin (n = 35), 59% ± 10.4 (P
Keywords
Pediatrics, Perinatology, and Child Health
Citation
Lemmers, P M A, Benders, M J N L, D'Ascenzo, R, Zethof, J, Alderliesten, T, Kersbergen, K J, Isgum, I, de Vries, L S, Groenendaal, F & van Bel, F 2016, 'Patent ductus arteriosus and brain volume', Pediatrics, vol. 137, no. 4, e20153090. https://doi.org/10.1542/peds.2015-3090