Lysosomes nor Mice Move Forward without Borcs7
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Publication date
2018
Authors
Joshi, Urjita
Houwman, Joseline A
van der Sluijs, Peter
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Document Type
Article
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taverne
Abstract
Lysosome function and position in the cytoplasm depends on the BORCS machinery, which tethers lysosomes to the kinesin microtubule motor. A recent paper of Snouwaert et al. in Cell Reports characterizes a mouse with a spontaneous mutation in the Borcs7 subunit, which causes axonal dystrophy and impaired motor function.
Keywords
Borcs7, lysosome positioning, axonal dystrophy, autophagy, Taverne
Citation
Joshi, U, Houwman, J A & van der Sluijs, P 2018, 'Lysosomes nor Mice Move Forward without Borcs7', Trends in Cell Biology, vol. 28, no. 10, pp. 761-763. https://doi.org/10.1016/j.tcb.2018.08.002