Thinner inner retinal layers are associated with lower cognitive performance, lower brain volume, and altered white matter network structure-The Maastricht Study
Publication date
2024-01
Authors
van der Heide, Frank C T
Steens, Indra L M
Limmen, Betsie
Mokhtar, Sara
van Boxtel, Martin P J
Schram, Miranda T
Köhler, Sebastian
Kroon, Abraham A
van der Kallen, Carla J H
Dagnelie, Pieter C
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Supervisors
Document Type
Article
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Abstract
INTRODUCTION: The retina may provide non-invasive, scalable biomarkers for monitoring cerebral neurodegeneration. METHODS: We used cross-sectional data from The Maastricht study (n = 3436; mean age 59.3 years; 48% men; and 21% with type 2 diabetes [the latter oversampled by design]). We evaluated associations of retinal nerve fiber layer, ganglion cell layer, and inner plexiform layer thicknesses with cognitive performance and magnetic resonance imaging indices (global grey and white matter volume, hippocampal volume, whole brain node degree, global efficiency, clustering coefficient, and local efficiency). RESULTS: After adjustment, lower thicknesses of most inner retinal layers were significantly associated with worse cognitive performance, lower grey and white matter volume, lower hippocampal volume, and worse brain white matter network structure assessed from lower whole brain node degree, lower global efficiency, higher clustering coefficient, and higher local efficiency. DISCUSSION: The retina may provide biomarkers that are informative of cerebral neurodegenerative changes in the pathobiology of dementia.
Keywords
brain structural connectivity, brain volume, clustering coefficient, cognitive function, cognitive performance, global efficiency, graph theory, grey matter, local efficiency, magnetic resonance imaging (MRI), optical coherence tomography (OCT), retinal imaging, retinal neurodegeneration, white matter, whole brain node degree, Clinical Neurology, Geriatrics and Gerontology, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Health Policy, Developmental Neuroscience, Epidemiology, Journal Article
Citation
van der Heide, F C T, Steens, I L M, Limmen, B, Mokhtar, S, van Boxtel, M P J, Schram, M T, Köhler, S, Kroon, A A, van der Kallen, C J H, Dagnelie, P C, van Dongen, M C J M, Eussen, S J P M, Berendschot, T T J M, Webers, C A B, van Greevenbroek, M M J, Koster, A, van Sloten, T T, Jansen, J F A, Backes, W H & Stehouwer, C D A 2024, 'Thinner inner retinal layers are associated with lower cognitive performance, lower brain volume, and altered white matter network structure-The Maastricht Study', Alzheimer's & Dementia , vol. 20, no. 1, pp. 316-329. https://doi.org/10.1002/alz.13442