Clomifeencitraat voor hypogonadale klachten: bijna 10 jaar ervaring

Abstract

Hypogonadism, is a worldwide problem among men that causes sexual, physical and mental problems. Clomiphene citrate (CC) is an alternative, off-label therapy, especially for men with an active or future child wish. In this single-center study, 153 men treated with CC for hypogonadism were retrospectively analyzed. Outcome measures included hormonal evaluation, hypogonadal symptoms, metabolic and lipid parameters, safety aspects and side-effects. During treatment, total testosterone increased from 9 to 16 nmol/l, with a biochemical improvement in 89% of the patients. Increased levels of total testosterone held after eight years of treatment. With CC treatment, 74% of patients experienced improvement of hypogonadal symptoms. Low to normal luteinizing hormone before CC treatment was a predictor for better testosterone response. Few, non-serious side-effects were reported during CC therapy. In conclusion, CC is an effective short- and long-term treatment, improving both clinical symptoms and biochemical aspects of male hypogonadism, with few side-effects and good safety aspects.