Genome-wide association study of osteochondrosis in the tarsocrural joint of Dutch Warmblood horses identifies susceptibility loci on chromosomes 3 and 10
Files
Publication date
2013-08
Authors
Orr, N
Hill, E W
Gu, J
Govindarajan, P
Conroy, J
van Grevenhof, E M
Ducro, B J
van Arendonk, J.A.M.
Knaap, J H
van Weeren, René
Editors
Advisors
Supervisors
Document Type
Article
Metadata
Show full item recordCollections
License
Abstract
Equine osteochondrosis is a developmental joint disease that is a significant source of morbidity affecting multiple breeds of horse. The genetic variants underlying osteochondrosis susceptibility have not been established. Here, we describe the results of a genome-wide association study of osteochondrosis using 90 cases and 111 controls from a population of Dutch Warmblood horses. We report putative associations between osteochondrosis and loci on chromosome 3 (BIEC2-808543; P = 5.03 × 10(-7) ) and chromosome 10 (BIEC2-121323; P = 2.62 × 10(-7) ).
Keywords
Citation
Orr, N, Hill, E W, Gu, J, Govindarajan, P, Conroy, J, van Grevenhof, E M, Ducro, B J, van Arendonk, J A M, Knaap, J H, van Weeren, P R, Machugh, D E, Ennis, S & Brama, P A J 2013, 'Genome-wide association study of osteochondrosis in the tarsocrural joint of Dutch Warmblood horses identifies susceptibility loci on chromosomes 3 and 10', Animal Genetics, vol. 44, no. 4, pp. 408-412. https://doi.org/10.1111/age.12016