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RNA interference mechanisms and therapeutic applications

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Publication date

2006

Authors

Lamers, Anne E.
de Kleijn, Dominique P.V.ORCID 0000-0003-2714-2140

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DOI

https://doi.org/10.1007/0-387-23329-6_7

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Part of book

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Abstract

RNA interference (RNAi) is a technology developed after the recent discovery of well-conserved cellular processes that induce posttranscriptional gene silencing triggered by small fragments of double-stranded RNA. This technique is rapidly developing into a promising tool used for functional genetics and therapeutic applications. We focus here on the aspects concerning RNAi mechanism, applications in mammals, and construct design and delivery. We summarize some therapeutic applications in general and speculate on the relevance in cardiovascular medicine.

Keywords

General Medicine

Citation

Lamers, A E & De Kleijn, D P V 2006, RNA interference mechanisms and therapeutic applications. in Cardiovascular Research : New Technologies, Methods, and Applications. Springer, pp. 121-130. https://doi.org/10.1007/0-387-23329-6_7

URI

http://hdl.handle.net/1874/457247