Wnt/β-catenin signaling in adult mammalian epithelial stem cells
Publication date
2017-08-15
Authors
Kretzschmar, Kai
Clevers, Hans
Editors
Advisors
Supervisors
Document Type
Article
Metadata
Show full item recordCollections
License
Abstract
Adult stem cells self-renew and replenish differentiated cells in various organs and tissues throughout a mammal's life. Over the last 25 years an ever-growing body of knowledge has unraveled the essential regulation of adult mammalian epithelia by the canonical Wnt signaling with its key intracellular effector β-catenin. In this review, we discuss the principles of the signaling pathway and its role in adult epithelial stem cells of the intestine and skin during homeostasis and tumorigenesis. We further highlight the research that led to the identification of new stem cell markers and methods to study adult stem cells ex vivo.
Keywords
Adult Stem Cells, Animals, Cell Self Renewal, Epidermis, Epithelial Cells, Humans, Intestinal Mucosa, Models, Biological, Wnt Signaling Pathway, beta Catenin, Journal Article, Review, Research Support, Non-U.S. Gov't, Molecular Biology, Developmental Biology, Cell Biology, Journal Article, Review
Citation
Kretzschmar, K & Clevers, H 2017, 'Wnt/β-catenin signaling in adult mammalian epithelial stem cells', Developmental Biology, vol. 428, no. 2, pp. 273-282. https://doi.org/10.1016/j.ydbio.2017.05.015