Localization of human antigen-specific helper and suppressor function in distinct T-cell subpopulations

Abstract

Distinct human T-cell subpopulations were isolated and cultured in the presence of B-cells and antigens. After an incubation period of 6 days cells were tested for their capacity to secrete antigen-specific antibodies in the PFC-assay. The results indicate that the T-helper activity for the antigen-induced T-dependent B-cell differentiation is located in the Tμ-subpopulation, whereas the suppressor-cell activity is confined to the Tγ-subpopulation.