Characterization of pKP-M1144, a Novel ColE1-like plasmid encoding IMP-8, GES-5, and BEL-1 β-lactamases, from a Klebsiella pneumoniae sequence type 252 isolate
Publication date
2015-08-01
Authors
Papagiannitsis, Costas C.
Dolejska, Monika
Izdebski, Radoslaw
Dobiasova, Hana
Studentova, Vendula
Esteves, Francisco J.
Derde, Lennie P G
Bonten, Marc
Hrabák, Jaroslav
Gniadkowski, Marek
Editors
Advisors
Supervisors
Document Type
Article
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taverne
Abstract
IMP-8 metallo-β-lactamase was identified in Klebsiella pneumoniae sequence type 252 (ST252), isolated in a Portuguese hospital in 2009. bla<inf>IMP-8</inf> was the first gene cassette of a novel class 3 integron, In1144, also carrying the bla<inf>GES-5</inf>, bla<inf>BEL-1</inf>, and aacA4 cassettes. In1144 was located on a ColE1-like plasmid, pKP-M1144 (12,029 bp), with a replication region of limited nucleotide similarity to those of other RNA-priming plasmids, such as pJHCMW1. In1144 and pKP-M1144 represent an interesting case of evolution of resistance determinants in Gram-negative bacteria.
Keywords
Taverne, Pharmacology (medical), Pharmacology, Infectious Diseases
Citation
Papagiannitsis, C C, Dolejska, M, Izdebski, R, Dobiasova, H, Studentova, V, Esteves, F J, Derde, L P G, Bonten, M J M, Hrabák, J & Gniadkowski, M 2015, 'Characterization of pKP-M1144, a Novel ColE1-like plasmid encoding IMP-8, GES-5, and BEL-1 β-lactamases, from a Klebsiella pneumoniae sequence type 252 isolate', Antimicrobial Agents and Chemotherapy, vol. 59, no. 8, pp. 5065-5068. https://doi.org/10.1128/AAC.00937-15