World Marrow Donor Association guidelines for the reporting of novel HLA alleles
Publication date
2023-07
Authors
Hofmann, Jan A
Bochtler, Werner
Robinson, James
Sauter, Jürgen
Askar, Medhat
Houdova, Lucie
Melchers, Mark
Schmidt, Alexander H
Spierings, Eric
Urban, Christine
Editors
Advisors
Supervisors
Document Type
Article
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License
cc_by_nc_nd
Abstract
The guidelines for the implementation and reporting of HLA nomenclature for the World Marrow Donor Association have served as a reliable standard for communication of HLA data in the hematopoietic cell transplantation process. Wider use of next-generation sequencing made a special provision of the guidelines increasingly pertinent: how to communicate novel HLA alleles. Novel alleles need to be recognized by the WHO Nomenclature Committee for Factors of the HLA system to obtain official allele designations. Until then they have to be handled according to the specific rules. Leaving the actual rules basically unchanged we give some advice on how to communicate novel alleles to best facilitate the search process for cases where novel alleles are identified on donor or patient side.
Keywords
donor registry, HLA, new alleles, NGS typing, patient registry, Genetics, Immunology and Allergy, Immunology, Journal Article
Citation
Hofmann, J A, Bochtler, W, Robinson, J, Sauter, J, Askar, M, Houdova, L, Melchers, M, Schmidt, A H, Spierings, E, Urban, C, Venter, A, Maiers, M, Marsh, S G E & Eberhard, H-P 2023, 'World Marrow Donor Association guidelines for the reporting of novel HLA alleles', HLA, vol. 102, no. 1, pp. 62-64. https://doi.org/10.1111/tan.15048