Regulation of initiation of DNA synthesis in relation to mitosis in cultured hepatoma cells
Publication date
1979-08
Authors
Wijk, R. van
Zoutewelle, G.
Poll, K.W. van de
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Document Type
Article
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Abstract
The commitment of Reuber H 35 hepatoma cells to DNA synthesis was studied by exposing cells which were synchronized by serum depletion, to serum. It is shown that the period of commitment is 6–8 hr, independent of the length of the G1 phase. It can even occur during the G2 period of the previous cell cycle.