Systematic review indicates postnatal growth in term infants born small-for-gestational-age being associated with later neurocognitive and metabolic outcomes
Publication date
2017-08-01
Authors
Castanys-Muñoz, Esther
Kennedy, Kathy
Castañeda-Gutiérrez, Eurídice
Forsyth, Stewart
Godfrey, Keith M.
Koletzko, Berthold
Ozanne, Susan E.
Rueda, Ricardo
Schoemaker, Marieke H.
van der Beek, Eline M
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Document Type
Article
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Abstract
We systematically reviewed papers published in English between 1994 and October 2015 on how postnatal weight gain and growth affect neurodevelopment and metabolic outcomes in term-born small-for-gestational-age (SGA) infants. Two randomised trials reported that enriched infant formulas that promoted early growth also increased fat mass, lean mass and blood pressure (BP), but had no effect on early neurocognitive outcomes. Meanwhile, 31 observational studies reported consistent positive associations between postnatal weight gain and growth with neurocognitive outcomes, adiposity, insulin resistance and BP. Conclusion: Few intervention studies exist, despite consistent positive associations between early growth and neurocognition in term-born SGA infants.
Keywords
Adiposity, Insulin resistance, Neurodevelopment, Postnatal growth, Small for gestational age, Pediatrics, Perinatology, and Child Health
Citation
Castanys-Muñoz, E, Kennedy, K, Castañeda-Gutiérrez, E, Forsyth, S, Godfrey, K M, Koletzko, B, Ozanne, S E, Rueda, R, Schoemaker, M H, van der Beek, E M, van Buuren, S & Ong, K K 2017, 'Systematic review indicates postnatal growth in term infants born small-for-gestational-age being associated with later neurocognitive and metabolic outcomes', Acta Paediatrica, International Journal of Paediatrics, vol. 106, no. 8, pp. 1230-1238. https://doi.org/10.1111/apa.13868