Treatment Time or Convection Volume in HDF: What Drives the Reduced Mortality Risk?
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Publication date
2015-08
Authors
De Roij Van Zuijdewijn, Camiel L M
Nubé, Menso J.
ter Wee, Piet M.
Blankestijn, Peter J.
Lévesque, Renée
van den Dorpel, Marinus A.
Bots, Michiel L
Grooteman, Muriel P C
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Document Type
Article
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taverne
Abstract
Background/Aims: Treatment time is associated with survival in hemodialysis (HD) patients and with convection volume in hemodiafiltration (HDF) patients. High-volume HDF is associated with improved survival. Therefore, we investigated whether this survival benefit is explained by treatment time. Methods: Participants were subdivided into four groups: HD and tertiles of convection volume in HDF. Three Cox regression models were fitted to calculate hazard ratios (HRs) for mortality of HDF subgroups versus HD: (1) crude, (2) adjusted for confounders, (3) model 2 plus mean treatment time. As the only difference between the latter models is treatment time, any change in HRs is due to this variable. Results: 114/700 analyzed individuals were treated with high-volume HDF. HRs of high-volume HDF are 0.61, 0.62 and 0.64 in the three models, respectively (p values <0.05). Confidence intervals of models 2 and 3 overlap. Conclusion: The survival benefit of high-volume HDF over HD is independent of treatment time.
Keywords
Taverne, Nephrology, Hematology, Journal Article, Research Support, Non-U.S. Gov't
Citation
de Roij van Zuijdewijn, C L M, Nubé, M J, ter Wee, P M, Blankestijn, P J, Lévesque, R, van den Dorpel, M A, Bots, M L & Grooteman, M P C 2015, 'Treatment Time or Convection Volume in HDF : What Drives the Reduced Mortality Risk?', Blood Purification, vol. 40, no. 1, pp. 53-58. https://doi.org/10.1159/000430903