The HAUS Complex Is a Key Regulator of Non-centrosomal Microtubule Organization during Neuronal Development
Publication date
2018-07-24
Authors
Cunha-Ferreira, Inês
Chazeau, Anaël
Buijs, Robin R.
Stucchi, Riccardo
Will, Lena
Pan, Xingxiu
Adolfs, Youri
van der Meer, Christiaan
Wolthuis, Joanna C
Kahn, Olga I.
Editors
Advisors
Supervisors
Document Type
Article
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cc_by_nc_nd
Abstract
Cunha-Ferreira et al. report that the HAUS/augmin complex regulates neuronal migration, polarization, and development. In neurons, the HAUS complex is distributed as discrete clusters regulating local microtubule nucleation. These findings shed light into how microtubules are generated in developing neurons after centrosome inactivation in early development.
Keywords
actin, centrosome, development, microtubule, migration, neuron, nucleation, General Biochemistry,Genetics and Molecular Biology
Citation
Cunha-Ferreira, I, Chazeau, A, Buijs, R R, Stucchi, R, Will, L, Pan, X, Adolfs, Y, van der Meer, C, Wolthuis, J C, Kahn, O I, Schätzle, P, Altelaar, M, Pasterkamp, R J, Kapitein, L C & Hoogenraad, C C 2018, 'The HAUS Complex Is a Key Regulator of Non-centrosomal Microtubule Organization during Neuronal Development', Cell Reports, vol. 24, no. 4, pp. 791-800. https://doi.org/10.1016/j.celrep.2018.06.093