Effects of hypophysectomy and ACTH1–10 on responsiveness to electric shock in rats
Publication date
1967-02
Authors
Gispen, W.H.
Wimersma Greidanus, T.B. van
Wied, D. de
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Document Type
Article
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Abstract
Response behavior of rats to unescapable electric shock was studied in intact and hypophysectomized animals. The threshold for flinch, jerk, run and jump was significantly lowered in hypophysectomized rats as compared to that of intact controls. Treatment with the ACTH analogue ACTH1–10 did not affect threshold levels in hypophysectomized nor in intact rats. It is concluded that the stimulating effect of ACTH1–10 on conditioned avoidance acquisition in hypophysectomized rats is not caused by an influence on sensory capacities.
Keywords
Hypophysectomy ACTH1–10, Electric shock, Flinch, Jerk, Run, Jump