Pre-hospital treatment with crushed versus integral tablets of prasugrel in patients presenting with ST-Segment Elevation Myocardial Infarction-1-year follow-up results of the COMPARE CRUSH trial: One-year results from the COMPARE CRUSH trial
Publication date
2022-10
Authors
Vogel, Rosanne Francina
Delewi, Ronak
Wilschut, Jeroen M
Lemmert, Miguel E
Diletti, Roberto
van Vliet, Ria
van der Waarden, Nancy W P L
Nuis, Rutger-Jan
Paradies, Valeria
Alexopoulos, Dimitrios
Editors
Advisors
Supervisors
Document Type
Article
Metadata
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License
taverne
Abstract
The present research letter reports the 1-year clinical outcomes of the randomized COMPARE CRUSH trial, which allocated STEMI patients at first medical contact in the ambulance to receive either crushed or integral tablets of prasugrel loading dose. This trial aimed to investigate whether early enhanced antiplatelet effect constituted by the crushed potent oral P2Y 12 inhibitor prasugrel could lead to improved early myocardial reperfusion and clinical outcomes.
Keywords
Taverne, Cardiology and Cardiovascular Medicine, Letter
Citation
Vogel, R F, Delewi, R, Wilschut, J M, Lemmert, M E, Diletti, R, van Vliet, R, van der Waarden, N W P L, Nuis, R-J, Paradies, V, Alexopoulos, D, Zijlstra, F, Montalescot, G, Angiolillo, D J, Krucoff, M W, Smits, P C, Van Mieghem, N M & Vlachojannis, G J 2022, 'Pre-hospital treatment with crushed versus integral tablets of prasugrel in patients presenting with ST-Segment Elevation Myocardial Infarction-1-year follow-up results of the COMPARE CRUSH trial : One-year results from the COMPARE CRUSH trial', American Heart Journal, vol. 252, pp. 26-30. https://doi.org/10.1016/j.ahj.2022.05.022