Thromboembolic events and apparent heparin resistance in patients infected with SARS-CoV-2
Publication date
2020-06
Authors
Beun, Robert
Kusadasi, Nuray
Sikma, M A
Westerink, Jan
Huisman, Albert
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Document Type
Comment
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Abstract
In March 2020, the global healthcare system is overwhelmed by patients infected with SARS-CoV-2, which is the cause of the coronavirus pandemic (Covid-2019). A large number of these patients end up in the intensive care units (ICU) with critical illness requiring mechanical ventilation. One of the most important clinical features of the infection is a profound coagulopathy. In a recent cohort study 71% of patients who eventually died matched the ISTH criteria for disseminated intravascular coagulation (DIC), while this percentage was only 0.6% in patients who survived.
Keywords
COVID19, SARS-CoV-2, corona, SARS, heparin, Intensive Care Units, Pandemics, Humans, Middle Aged, Pulmonary Embolism/complications, Drug Tolerance, Male, Anticoagulants/therapeutic use, Factor Xa/analysis, Betacoronavirus/isolation & purification, Drug Monitoring/methods, Factor VIII/analysis, Clinical Laboratory Techniques/methods, Fibrinogen/analysis, Pneumonia, Viral/complications, Biomarkers/blood, Female, Heparin/therapeutic use, Aged, Coronavirus Infections/complications, Fibrin Fibrinogen Degradation Products/analysis, Cohort Studies, Disseminated Intravascular Coagulation/complications, Biochemistry, medical, Hematology, Clinical Biochemistry, Letter
Citation
Beun, R, Kusadasi, N, Sikma, M, Westerink, J & Huisman, A 2020, 'Thromboembolic events and apparent heparin resistance in patients infected with SARS-CoV-2', International Journal of Laboratory Hematology, vol. 42, no. S1, pp. 19-20. https://doi.org/10.1111/ijlh.13230