Rapid Rebound of a Preexisting CXCR4-tropic Human Immunodeficiency Virus Variant After Allogeneic Transplantation With CCR5 Δ32 Homozygous Stem Cells
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Publication date
2019-02-15
Authors
Verheyen, Jens
Thielen, Alexander
Lübke, Nadine
Dirks, Miriam
Widera, Marek
Dittmer, Ulf
Kordelas, Lambros
Däumer, Martin
de Jong, Dorien
Wensing, Anne(marie)
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Article
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taverne
Abstract
Allogeneic stem cell transplantation (alloSCT) of homozygous CCR5 δ32 stem cells once resulted in the cure of human immunodeficiency virus (HIV) infection. We have recently reported a viral breakthrough in a similar setting. Here, we demonstrate that the rapid rebound after alloSCT was related to a highly replicative CXCR4-tropic HIV variant, which could already be detected before alloSCT.
Keywords
AlloSCT, Cure, HIV-1, Rebound, δ32 stem cells, rebound, cure, alloSCT, Delta 32 stem cells, Taverne, Microbiology (medical), Infectious Diseases
Citation
Verheyen, J, Thielen, A, Lübke, N, Dirks, M, Widera, M, Dittmer, U, Kordelas, L, Däumer, M, De Jong, D C M, Wensing, A M J, Kaiser, R, Nijhuis, M & Esser, S 2019, 'Rapid Rebound of a Preexisting CXCR4-tropic Human Immunodeficiency Virus Variant After Allogeneic Transplantation With CCR5 Δ32 Homozygous Stem Cells', Clinical Infectious Diseases, vol. 68, no. 4, pp. 684-687. https://doi.org/10.1093/cid/ciy565