Double J-domain piloting of an Hsp70 substrate
Publication date
2021-01
Authors
Aragonès Pedrola, Júlia
Rüdiger, S.G.D.
Editors
Advisors
Supervisors
Document Type
Editorial
Metadata
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Abstract
Heat shock 70 kDa protein (Hsp70) chaperones play a crucial role in the biogenesis of tail-anchored proteins (TAs), starting a downstream cascade to the endoplasmic reticulum (ER) via the guided-entry-of-tail-anchored protein (GET) pathway. J-domain proteins (JDPs) are generally known to assist Hsp70s, but their specific role in TA targeting remains unclear. Cho et al. now identify two separate functions for JDPs in the process, in the initial capture of the TA and the transfer into the GET pathway. These data suggest that several Hsp70 cycles could be involved at distinct steps during protein maturation.
Keywords
Endoplasmic Reticulum/metabolism, HSP70 Heat-Shock Proteins/metabolism, Protein Binding, Protein Domains, Substrate Specificity
Citation
Pedrola, J A & Rüdiger, S G D 2021, 'Double J-domain piloting of an Hsp70 substrate', Journal of Biological Chemistry, vol. 296, 100717, pp. 1-2. https://doi.org/10.1016/j.jbc.2021.100717